Allometric analyses suggest that there are some developmental constraints on brain evolution. However, when one compares animals of similar body size, these constraints do not appear to be very tight. Moreover, the constraints often differ between taxonomic groups. Therefore, one may ask not only what causes developmental constraints but also how (and why) these constraints might be altered (or circumvented) during the course of evolution.

Overall, most of the reviewers agree that Principles of Brain Evolution was a welcome addition to the field, and kindly describe it as carefully researched and lucidly written. Thereafter, they note some gaps – principally, adaptive scenarios, microevolutionary studies, and computational models. I here admit to those deficiencies but explain why they exist and how they might be filled. In addition, one commentator criticizes my analysis of hominin brain evolution, and another finds my principle of “large equals well-connected” to be (...) inconsistent with the data. I rebut those two critiques. Hopefully, this process of critique and counterpoint will stimulate some readers to pursue the mentioned thoughts and to engage in new research. (shrink)

Instead of arguing for a specific animal model, Striedter will review the history and philosophy of animal models in biomedical research, examining their various advantages and limitations.